Nifedipine (NFP) is the prototype nitro-dihydropyridine calcium channel antagonist that is used to treat a variety of cardiovascular disorders. NFP is a BCS class II drug having low solubility in water which leads to low dissolution rate, slow onset of action and variable oral bioavailability. To improve the dissolution rate of NFP by preparing binary and ternary solid dispersions. Binary and ternary solid dispersions were prepared using polyvinyl pyrrolidone K30 (PVPK30) and poloxamer 407 (PLX407) in different weight ratios. The drug and the formulations were characterized by FTIR, DSC and XRD. Solubility analysis and In-vitro dissolution of NFP solid dispersions (binary and ternary) were carried out and then compared. In contrast to the very slow dissolution rate of pure NFP, the solid dispersions showed enhanced dissolution rate. The solubility and dissolution were increased in the order; NFP (Pure drug) < binary solid dispersions < ternary solid dispersions. The fraction of NFP dissolved after 1 hr was approximately 70% and 90% from binary (NFP: PVPK30; 1:8) and ternary solid dispersions (NFP: PVPK30:PLX407; 1:8:2) respectively in comparison to the pure NFP, which was found to be approximately 2% in 1 hr. From this study, it was concluded that NFP showed significant improvement (statistically analyzed using ANOVA) in dissolution rate in case of ternary dispersions as compared to the binary dispersions as well as pure NFP.
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